TSLP is a direct trigger for T cell migration in filaggrin-deficient skin equivalents

Chapter 2 Gingiva equivalents secrete negligible amounts of key chemokines involved in Langerhans Cell migration compared to skin equivalents

Chapter 2 Gingiva equivalents secrete negligible amounts of key chemokines involved in Langerhans Cell migration compared to skin equivalents

Gingiva Equivalents Secrete Negligible Amounts of Key Chemokines Involved in Langerhans Cell Migration Compared to Skin Equivalents

Both oral mucosa and skin have the capacity to maintain immune homeostasis or regulate immune responses upon environmental assault. Whereas much is known about key innate immune events in skin, little is known about oral mucosa. Comparative studies are limited due to the scarce supply of oral mucosa for ex vivo studies. Therefore, we used organotypic tissue equivalents (reconstructed epithelium...

Redox Status Is Critical for Stemness in Skin Equivalents

The skin is constantly exposed to environmental oxidative stress. Skin equivalent (SE) models are three-dimensional systems in which cell-cell or cell-matrix interactions can be investigated. In this study, the effects of vitamin C or plant extracts with high antioxidant activities were tested. There was no significant difference in the epidermal thickness, but the basal cells became cuboidal w...

γδ T cell homing to skin and migration to skin-draining lymph nodes is CCR7 independent.

In most species, γδ T cells preferentially reside in epithelial tissues like the skin. Lymph duct cannulation experiments in cattle revealed that bovine dermal γδ T cells are able to migrate from the skin to the draining lymph nodes via the afferent lymph. For αβ T cells, it is generally accepted that epithelial and mucosal tissue egress is regulated by expression of the CCR7 chemokine receptor...

gd T Cell Homing to Skin and Migration to Skin-Draining Lymph Nodes Is CCR7 Independent